Two Novel Polysaccharides inL and anti-A549 Lung Cancer Cells Activity.
Molecules. 2019 Oct 16 ;24(20). Epub 2019 Oct 16. PMID: 31623207
Two novel water soluble heteroglycan (PCp-I and PCp-II) with anti-A549 lung cancer cells activity were isolated fromL. Their average molecular weights were 2.721× 10and 2.850× 10. PCp-I and PCp-II had the same monosaccharide composition, but their molar ratios were different. Based on methylation and NMR spectroscopy, the part structure of PCp-I was identified. The results of scanning electron microscope (SEM) showed that PCp-I had an irregular porous structure and PCp-II was flaky and irregularly curved. The results of thermogravimetry-differential scanning calorimetry (TG-DSC) showed that PCp-I and PCp-II had good thermal stability. Furthermore, PCp-I and PCp-II exhibited significant anti-A549 lung cancer cells activity (IC= 64.84 and 126.30μM).