Long-Term Exposure to Ambient Fine Particulate Matter () and Lung Function in Children, Adolescents, and Young Adults: A Longitudinal Cohort Study.
Environ Health Perspect. 2019 Dec ;127(12):127008. Epub 2019 Dec 24. PMID: 31873044
BACKGROUND: The association between long-term exposure to ambient fine particulate matter with aerodynamic diameter() and lung function in young people remains uncertain, particularly in Asia, where air pollution is generally a serious problem.
OBJECTIVES: This study investigated the association between long-term exposure to ambientand lung function in Taiwanese children, adolescents, and young adults.
METHODS: This study comprised 24,544 participants 6-24 years of age, with 33,506 medical observations made between 2000 and 2014. We used a spatiotemporal model to estimateconcentrations at participants' addresses. Spirometry parameters, i.e., forced vital capacity (FVC), forced expiratory volume in 1 s (), and maximum midexpiratory flow (MMEF), were determined. A generalized linear mixed model was used to examine the associations between long-term exposure to ambientand lung function. The odds ratios (ORs) of poor lung function were also calculated after adjusting for a range of covariates.
RESULTS: Everyincrease in the 2-y averageconcentration was associated with decreases of 2.22% [95% confidence interval (CI):,], 2.94 (95% CI:,), and 2.79% (95% CI:,) in the FVC,, and MMEF, respectively. Furthermore, it was associated with a 20% increase in the prevalence of poor lung function (OR: 1.20; 95% CI: 1.12, 1.29).
CONCLUSIONS: Two-year ambientconcentrations were inversely associated with lung function and positively associated with the prevalence of poor lung function in children, adolescents, and young adults in Taiwan. https://doi.org/10.1289/EHP5220.