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Abstract Title:

Tunneling effect in regeneration reaction of vitamin E by ubiquinol.

Abstract Source:

J Allergy Clin Immunol. 2005 Jun;115(6):1176-83. PMID: 20415458

Abstract Author(s):

Aya Ouchi, Shin-ichi Nagaoka, Kazuo Mukai

Article Affiliation:

Department of Chemistry, Faculty of Science, Ehime University, Matsuyama 790-8577, Japan. oouchi@chem.sci.ehime-u.ac.jp

Abstract:

A kinetic study of the regeneration reaction of vitamin E by ubiquinol was carried out by means of double-mixing stopped-flow spectroscopy. A substantial deuterium kinetic-isotope effect was observed on the second-order rate constant and the activation energy. In the regeneration reaction of alpha-tocopherol, deuteration of ubiquinol increased and decreased the activation energy and the second-order rate constant by 6.1 kJ/mol and a factor of 18.3, respectively. From this result, it is considered that proton tunneling plays an important role in the regeneration reaction of vitamin E by ubiquinol. The conditions under which the tunneling effect becomes an important factor were discussed in conjunction of our experimental results.

Study Type : Commentary

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