Article Publish Status: FREE
Abstract Title:

Ubiquinol improves symptoms in children with autism.

Abstract Source:

Oxid Med Cell Longev. 2014 ;2014:798957. Epub 2014 Feb 23. PMID: 24707344

Abstract Author(s):

Anna Gvozdjáková, Jarmila Kucharská, Daniela Ostatníková, Katarína Babinská, Dalibor Nakládal, Fred L Crane

Article Affiliation:

Anna Gvozdjáková


BACKGROUND: Autism is a spectrum of neurodevelopmental disorders with manifestation within 3 years after birth. Manifestations of autism include behavior problems (hyperactivity, toys destruction, self-harm, and aggression) and sleep and eating disorders. Etiology of autism is poorly understood. Oxidative stress and antioxidants can participate in pathobiochemical mechanisms of autism.

METHODS: Twenty-four children, aged 3-6 years, with autism according to the DSM IV criteria and using CARS were included in the study. Concentrations of CoQ10-TOTAL,γ- and α-tocopherol, β-carotene, and lipid peroxidation were determined in plasma before and after three months of supportive therapy with ubiquinol at a daily dose 2 × 50 mg. Data on behavior of the children were collected from parents at the same time.

RESULTS: Ubiquinol supportive therapy improved symptoms in children with autism, as communication with parents (in 12%), verbal communication (in 21%), playing games of children (in 42%), sleeping (in 34%), and food rejection (in 17%), with CoQ10-TOTAL plasma level above 2.5μmol/L.

CONCLUSIONS: Beneficial effect of ubiquinol in children with autism has been demonstrated for the first time. We assume that plasma concentration of CoQ10-TOTAL and lipid peroxidation could be used as relevant biomarkers of ubiquinol supportive therapy.

Study Type : Human Study
Additional Links
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758)

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