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Article Publish Status: FREE
Abstract Title:

Unique Triterpenoid of Jujube Root Protects Cisplatin-induced Damage in Kidney Epithelial LLC-PK1 Cells via Autophagy Regulation.

Abstract Source:

Nutrients. 2020 Mar 2 ;12(3). Epub 2020 Mar 2. PMID: 32131519

Abstract Author(s):

Dahae Lee, Kyo Bin Kang, Hyun Woo Kim, Jung Sik Park, Gwi Seo Hwang, Ki Sung Kang, Sungyoul Choi, Noriko Yamabe, Ki Hyun Kim

Article Affiliation:

Dahae Lee

Abstract:

Chronic exposure to cisplatin is associated with irreversible kidney impairment. In this present study, we explored the protective effects of 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME) isolated from roots of jujube (, Rhamnaceae) against cisplatin-induced damage in vitro. In kidney epithelial LLC-PK1 cells, western blotting and staining with specific autophagy epifluorescent dye CytoID were used to determine the molecular pathways involving autophagy. Treatment with 3DC2ME reduced the increased Cyto-ID-stained autophagic vesicles and reversed the protein expressions of 5' AMP-activated protein kinase subunitβ-1 (AMPK)/mammalian target of rapamycin (mTOR)-dependent signaling pathway in cisplatin-induced cell death. Additionally, treatment with autophagy inhibitor 3-methyladenine (3-MA) and with or without 3DC2ME attenuated the cisplatin-induced apoptosis. Although further research is necessary to substantiate the effects, we evaluated the potential mechanism of action of 3DC2ME as an adjuvant for cancer patients.

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Sayer Ji
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