Urban Air Pollution Particulates Suppress Human T-Cell Responses to.
Int J Environ Res Public Health. 2019 10 25 ;16(21). Epub 2019 Oct 25. PMID: 31731429
Tuberculosis (TB) and air pollution both contribute significantly to the global burden of disease. Epidemiological studies show that exposure to household and urban air pollution increase the risk of new infections with(M.tb) and the development of TB in persons infected withand alter treatment outcomes. There is increasing evidence that particulate matter (PM) exposure weakens protective antimycobacterial host immunity. Mechanisms by which exposure to urban PM may adversely affect-specific human T cell functions have not been studied. We, therefore, explored the effects of urban air pollution(aerodynamic diameters≤2.5µm) on M.tb-specific T cell functions in human peripheral blood mononuclear cells (PBMC).exposure decreased the capacity of PBMC to control the growth of M.tb and the M.tb-induced expression of CD69, an early surface activation marker expressed on CD3T cells.exposure also decreased the production of IFN-γ in CD3, TNF-α in CD3and CD14M.tb-infected PBMC, and the M.tb-induced expression of T-box transcription factor TBX21 (T-bet). In contrast,exposure increased the expression of anti-inflammatory cytokine IL-10 in CD3and CD14PBMC. Taken together,exposure of PBMC prior to infection with M.tb impairs critical antimycobacterial T cell immune functions.