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Article Publish Status: FREE
Abstract Title:

Evaluation of Anti-Effect of Ursolic Acid as a Novel Toxoplasmosis Inhibitor.

Abstract Source:

Pharmaceuticals (Basel). 2018 May 9 ;11(2). Epub 2018 May 9. PMID: 29747388

Abstract Author(s):

Won Hyung Choi, In Ah Lee

Article Affiliation:

Won Hyung Choi

Abstract:

This study was carried out to evaluate the anti-parasitic effect of ursolic acid against() that induces toxoplasmosis, particularly in humans. The anti-parasitic effects of ursolic acid against-infected cells andwere evaluated through different specific assays, including immunofluorescence staining and animal testing. Ursolic acid effectively inhibited the proliferation ofwhen compared with sulfadiazine, and consistently induced anti-activity/effect. In particular, the formation of parasitophorous vacuole membrane (PVM) in host cells was markedly decreased after treating ursolic acid, which was effectively suppressed. Moreover, the survival rate ofwas strongly inhibited ingroup treated with ursolic acid, and then 50% inhibitory concentration (IC) againstwas measured as 94.62μg/mL. The-infected mice treated with ursolic acid indicated the same survival rates and activity as the normal group. These results demonstrate that ursolic acid causes anti-action and effect by strongly blocking the proliferation ofthrough the direct and the selective-inhibitory ability as well as increases the survival of-infected mice. This study shows that ursolic acid has the potential to be used as a promising anti-candidate substance for developing effective anti-parasitic drugs.

Study Type : In Vitro Study

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