Abstract Title:

Ursolic acid-loaded lipid-core nanocapsules reduce damage caused by estrogen deficiency in wound healing.

Abstract Source:

Colloids Surf B Biointerfaces. 2021 Mar 24 ;203:111720. Epub 2021 Mar 24. PMID: 33819820

Abstract Author(s):

Bruna Carletto, Adriana Yuriko Koga, Andressa Novatski, Rubiana Mara Mainardes, Leandro Cavalcante Lipinski, Paulo Vitor Farago

Article Affiliation:

Bruna Carletto


The skin aging process in women is accelerated due to decreases in serum estrogen levels triggered by the menopause process. Hence, poly(L-lactic acid) lipid-core nanocapsules containing ursolic acid (NPLA-UA) were developed using the interfacial deposition of the preformed polymer methodology as a strategy to reduce damages to the healing process caused by hormonal deficiency in ovariectomized rats. The colloidal suspensions of nanocapsules presented adequate size and morphology (254 and 375 nm), negative zeta potential (-31 and -37 mV), high encapsulation efficiency (99.89 %), and amorphous character. The analyses performed in an in vivo healing trial showed that the treatment with NPLA-UA resulted in faster wound retraction with less inflammatory response. In addition, the angiogenic process was stimulated increased synthesis of dermal collagen occurred. Ursolic acid-loaded, lipid-core nanocapsules are suitable for treating skin changes triggered by decreased estrogen in menopause.

Study Type : Animal Study

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