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Article Publish Status: FREE
Abstract Title:

Biophotonic markers of malignancy: Discriminating cancers using wavelength-specific biophotons.

Abstract Source:

Biochem Biophys Rep. 2018 Mar ;13:7-11. Epub 2017 Nov 20. PMID: 29202105

Abstract Author(s):

Nirosha J Murugan, Nicolas Rouleau, Lukasz M Karbowski, Michael A Persinger

Article Affiliation:

Nirosha J Murugan

Abstract:

Early detection is a critically important factor when successfully diagnosing and treating cancer. Whereas contemporary molecular techniques are capable of identifying biomarkers associated with cancer, surgical interventions are required to biopsy tissue. The common imaging alternative, positron-emission tomography (PET), involves the use of nuclear material which poses some risks. Novel, non-invasive techniques to assess the degree to which tissues express malignant properties are now needed. Recent developments in biophoton research have made it possible to discriminate cancerous cells from normal cells both in vitro and in vivo. The current study expands upon a growing body of literature where we classified and characterized malignant and non-malignant cell types according to their biophotonic activity. Using wavelength-exclusion filters, we demonstrate that ratios between infrared and ultraviolet photon emissions differentiate cancer and non-cancer cell types. Further, we identified photon sources associated with three filters (420-nm, 620-nm., and 950-nm) which classified cancer and non-cancer cell types. The temporal increases in biophoton emission within these wavelength bandwidths is shown to be coupled with intrisitic biomolecular events using Cosic's resonant recognition model. Together, the findings suggest that the use of wavelength-exclusion filters in biophotonic measurement can be employed to detect cancer in vitro.

Study Type : In Vitro Study
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Additional Keywords : Biophotons : CK(95) : AC(28)

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