n/a
Abstract Title:

Exposures to Electronic-Cigarette Aerosols Impair theSignaling during Mouse Lung Development.

Abstract Source:

Am J Physiol Lung Cell Mol Physiol. 2020 Feb 21. Epub 2020 Feb 21. PMID: 32083945

Abstract Author(s):

Alexandra Noel, Shannon Hansen, Anusha Zaman, Zakia Perveen, Rakeysha Pinkston, Ekhtear Hossain, Rui Xiao, Arthur Penn

Article Affiliation:

Alexandra Noel

Abstract:

Currently, more than 9 million American adults, including women of childbearing age, use electronic-cigarettes (e-cigs). Further, the prevalence of maternal vaping now approaching 10% is similar to that of maternal smoking. Little, however, is known about the effects of fetal exposures to nicotine-rich e-cig aerosols on lung development. In this study, we assessed whetherexposures to e-cig aerosols compromised lung development in mice. A third-generation e-cig device was used to expose pregnant BALB/c mice by inhalation to 36 mg/mL of nicotine-cinnamon flavored e-cig aerosols for 14 to 31 days. This included exposures for either 12 days before mating plus during gestation (preconception groups) or only during gestation (prenatal groups). Respective control mice were exposed to filtered-air. Sub-groups of offspring were sacrificed at birth or at 4 weeks of age. Compared to respective air-exposed controls, both preconception and prenatal exposures to e-cig aerosols significantly decreased the offspring birth weight and body length. In the preconception group, 7 inflammation-related genes were down-regulated, including 4 genes common to both dams and fetuses, denoting an e-cig immunosuppressive effect. Lung morphometry assessments of preconception e-cig-exposed offspring showed a significantly increased tissue fraction at birth. This result was supported by the down-regulation of 75 lung genes involved in thesignaling, which is essential to lung organogenesis. Thus, our data indicate that maternal vaping impairs pregnancy outcomes, alters fetal lung structure, and dysregulates thesignaling. This study provides experimental evidence for future regulations of e-cig products for pregnant women and developmentally vulnerable populations.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.