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Article Publish Status: FREE
Abstract Title:

Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae.

Abstract Source:

PLoS Pathog. 2015 Jul ;11(7):e1005034. Epub 2015 Jul 16. PMID: 26181911

Abstract Author(s):

Eleanor R Watkins, Bridget S Penman, José Lourenço, Caroline O Buckee, Martin C J Maiden, Sunetra Gupta

Article Affiliation:

Eleanor R Watkins

Abstract:

The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of>90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement (VISR). Here, using a combination of mathematical modelling and whole genome analysis, we show that targeting particular serotypes through vaccination can also cause their metabolic and virulence-associated components to transfer through recombination to non-vaccine serotypes: a phenomenon we term Vaccine-Induced Metabolic Shift (VIMS). Our results provide a novel explanation for changes observed in the population structure of the pneumococcus following vaccination, and have important implications for strain-targeted vaccination in a range of infectious disease systems.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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