Abstract Title:

Common and diverse features of cocirculating type 2 and 3 recombinant vaccine-derived polioviruses isolated from patients with poliomyelitis and healthy children.

Abstract Source:

J Infect Dis. 2012 May 1 ;205(9):1363-73. Epub 2012 Mar 29. PMID: 22457288

Abstract Author(s):

Marie-Line Joffret, Sophie Jégouic, Maël Bessaud, Jean Balanant, Coralie Tran, Valerie Caro, Barbara Holmblat, Richter Razafindratsimandresy, Jean-Marc Reynes, Mala Rakoto-Andrianarivelo, Francis Delpeyroux

Article Affiliation:

Département de Virologie, Institut Pasteur, Unité de Biologie des Virus Entériques, France.

Abstract:

BACKGROUND: Five cases of poliomyelitis due to type 2 or 3 recombinant vaccine-derived polioviruses (VDPVs) were reported in the Toliara province of Madagascar in 2005.

METHODS: We sequenced the genome of the VDPVs isolated from the patients and from 12 healthy children and characterized phenotypic aspects, including pathogenicity, in mice transgenic for the poliovirus receptor.

RESULTS: We identified 6 highly complex mosaic recombinant lineages composed of sequences derived from different vaccine polioviruses and other species C human enteroviruses (HEV-Cs). Most had some recombinant genome features in common and contained nucleotide sequences closely related to certain cocirculating coxsackie A virus isolates. However, they differed in terms of their recombinant characteristics or nucleotide substitutions and phenotypic features. All VDPVs were neurovirulent in mice.

CONCLUSIONS: This study confirms the genetic relationship between type 2 and 3 VDPVs, indicating that both types can be involved in a single outbreak of disease. Our results highlight the various ways in which a vaccine-derived poliovirus may become pathogenic in complex viral ecosystems, through frequent recombination events and mutations. Intertypic recombination between cocirculating HEV-Cs (including polioviruses) appears to be a common mechanism of genetic plasticity underlying transverse genetic variability.

Study Type : Review

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