Article Publish Status: FREE
Abstract Title:

leaves extract alleviates insulin resistance via AMPK independent pathway in C2C12 myotube model.

Abstract Source:

Biochem Biophys Rep. 2018 Jul ;14:182-187. Epub 2018 May 22. PMID: 29872751

Abstract Author(s):

Masao Yamasaki, Kensaku Hamada, Kento Fujii, Kazuo Nishiyama, Yumi Yamasaki, Hiroyuki Tari, Kaori Araki, Teruaki Arakawa

Article Affiliation:

Masao Yamasaki


Blueberry () leaf has recently attracted attention as an anti-obesity food component. In this study, we examined the effects of blueberry leaf extract (BLEx) on insulin signaling in C2C12 differentiated myoblasts. The results showed that BLEx promotes the intracellular uptake of 2-[-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-BDG) and phosphorylation of Akt under insulin stimulation. In addition, pretreatment with BLEx ameliorated TNF-α-nduced insulin resistance with regard to 2-NBDG uptake and Akt phosphorylation. Moreover, BLEx prevented the TNF-α-induced activation of JNK and NF-kB pathways and phosphorylation of IRS-1 at serine residue. BLEx failed to induce phosphorylation of AMPK as well as did not prevent the restorationof 2-NBDG uptake under TNF-α-induced insulin resistance. Overall, skeletal muscle is a putative target for the anti-diabetic effect of BLEx by amelioration of insulin resistance.

Study Type : In Vitro Study

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