n/a
Abstract Title:

Vasorelaxation effect of 18β-glycyrrhetinic acid on the thoracic aorta of rats: proposed mechanism.

Abstract Source:

Pharmazie. 2019 12 1 ;74(12):751-754. PMID: 31907117

Abstract Author(s):

Peng Zhang, Zhi Chang, Jiamei Yang, Jun Feng, Yang Yu, Yanmin Pei, Jialing Wang, Fang Zhao, Zhou Ru

Article Affiliation:

Peng Zhang

Abstract:

18β-Glycyrrhetinic acid (18β-GA) is an effective component extracted from the traditional Chinese medicine(Leguminosae) and has various biological activities. This study was performed to investigate the vasodilatory effects of 18β-GA on isolated rat thoracic aortic rings and explore the underlying mechanisms. The rings were obtained from normal Sprague-Dawley rats and then precontracted with norepinephrine (NE) (1 μM) or KCl (60 mM). 18β-GA (1.883-11.297mg/L) was added successively by cumulative dosing to observe and record the changes in the tension of the vascular ring. The effects of NG-nitro-l-arginine methylester (L-NAME), indomethacin (INDO), barium chloride (BaCl₂), 4-aminopyridine(4-AP), tetraethylammonium (TEA), and glibenclamide on the vascular diastolic function of 18β-GA were determined. 18β-GA substantially exhibited a dose-dependent vasorelaxant effect on the NE-induced and KCl-induced contractions of the rings. The integrity of the vascular endothelium had no influence on the 18β-GA-induced vasorelaxation effect in the rings. L-NAME and IDON showed no significant differences in their effects on this vasorelaxation process in the rings precontracted with NE. This result suggests that the vasorelaxation mechanism of 18β-GA may be independent of the vascular endotheliumBaCl₂ and 4-AP antagonized the vasorelaxation effect of 18β-GA, but TEA and glibenclamide showed no remarkable effect on the vasodilation of 18β-GA. Findings suggest that 18β-GA induces vasorelaxation in thoracic aortic rings via the receptor-operated Cachannels and voltage-operated Cachannels and the opening of inward rectifier potassium channels and voltage-operated potassium.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.