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Article Publish Status: FREE
Abstract Title:

Indole-3-carbinol (I3C) increases apoptosis, represses growth of cancer cells, and enhances adenovirus-mediated oncolysis.

Abstract Source:

Cancer Biol Ther. 2014 Sep ;15(9):1256-67. Epub 2014 Jun 27. PMID: 24972095

Abstract Author(s):

Lan Chen, Pei-Hsin Cheng, Xiao-Mei Rao, Kelly M McMasters, Heshan Sam Zhou

Article Affiliation:

Lan Chen

Abstract:

Epidemiological studies suggest that high intake of cruciferous vegetables is associated with a lower risk of cancer. Experiments have shown that indole-3-carbinol (I3C), a naturally occurring compound derived from cruciferous vegetables, exhibits potent anticarcinogenic properties in a wide range of cancers. In this study, we showed that higher doses of I3C (≥400 μM) induced apoptotic cancer cell death and lower doses of I3C (≤200 μM) repressed cancer cell growth concurrently with suppressed expression of cyclin E and its partner CDK2. Notably, we found that pretreatment with low doses of I3C enhanced Ad-mediated oncolysis and cytotoxicity of human carcinoma cells by synergistic upregulation of apoptosis. Thus, the vegetable compound I3C as a dietary supplement may benefit cancer prevention and improve Ad oncolytic therapies.

Study Type : In Vitro Study

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Sayer Ji
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