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Abstract Title:

Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis.

Abstract Source:

J Nat Prod. 2016 05 27 ;79(5):1459-63. Epub 2016 Apr 20. PMID: 27096224

Abstract Author(s):

Claudia C Maquiaveli, João F Lucon-Júnior, Simone Brogi, Giuseppe Campiani, Sandra Gemma, Paulo C Vieira, Edson R Silva

Article Affiliation:

Claudia C Maquiaveli

Abstract:

Verbascoside (1) is a phenylethanoid glycoside that has antileishmanial activity against Leishmania infantum and Leishmania donovani. In this study, we verified the activity of 1 on Leishmania amazonensis and arginase inhibition. Compound 1 showed an EC50 of 19μM against L. amazonensis promastigotes and is a competitive arginase inhibitor (Ki = 0.7 μM). Docking studies were performed to assess the interaction of 1 with arginase at the molecular level. Arginase is an enzyme of the polyamine biosynthesis pathway that is important to parasite infectivity,and the results of our study suggest that 1 could be useful to develop new approaches for treating leishmaniasis.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Leishmanicidal : CK(38) : AC(24)

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