Verbascoside inhibits promastigote growth and arginase activity of Leishmania amazonensis. - GreenMedInfo Summary
Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis.
J Nat Prod. 2016 05 27 ;79(5):1459-63. Epub 2016 Apr 20. PMID: 27096224
Claudia C Maquiaveli
Verbascoside (1) is a phenylethanoid glycoside that has antileishmanial activity against Leishmania infantum and Leishmania donovani. In this study, we verified the activity of 1 on Leishmania amazonensis and arginase inhibition. Compound 1 showed an EC50 of 19μM against L. amazonensis promastigotes and is a competitive arginase inhibitor (Ki = 0.7 μM). Docking studies were performed to assess the interaction of 1 with arginase at the molecular level. Arginase is an enzyme of the polyamine biosynthesis pathway that is important to parasite infectivity,and the results of our study suggest that 1 could be useful to develop new approaches for treating leishmaniasis.