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Abstract Title:

On the chemotherapeutic agents localization in tissue by means of snake venoms.

Abstract Source:

Med Hypotheses. 2017 Jul ;104:89-92. Epub 2017 May 26. PMID: 28673600

Abstract Author(s):

Oleksii S Rukhlenko, Georgy Th Guria, Andrey I Vorobiev

Article Affiliation:

Oleksii S Rukhlenko

Abstract:

The efficiency of anti-tumour drug strongly depends on its dose. Higher drug doses and exposure times usually result in better treatment. It is why the implementation of high-dose treatment is always attractive. However, most of the drug delivery techniques meet essential limitations. In isolated regional perfusion a tumour can be exposed to high-dose therapeutic influence but the target organ may be isolated from the rest of circulatory system only for a relatively short period of time. During systemic injection of anti-tumour agents dose limitations are dictated by side toxicity danger. Viperidae venoms are known to cause local stagnation of blood flow and blood-tissue exchange processes in the place of snakebite. In present paper we suggest to use Viperidae snake venoms in addition to anti-tumour drugs for regional anti-cancer therapy. We suppose that Viperidae venoms will assist in drug localization. We state that their usage will help in high-dosage therapy implementation.

Study Type : Review
Additional Links
Pharmacological Actions : Chemotherapeutic : CK(2328) : AC(1086)

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