Abstract Title:

Vitamin B6 improves the immunogenicity of cisplatin-induced cell death.

Abstract Source:

Oncoimmunology. 2014 Oct ;3(9):e955685. Epub 2014 Dec 13. PMID: 25941619

Abstract Author(s):

Fernando Aranda, Norma Bloy, Lorenzo Galluzzi, Guido Kroemer, Laura Senovilla

Article Affiliation:

Fernando Aranda

Abstract:

We have recently demonstrated that pyridoxine, a precursor of vitamin B6, increases the immunogenicity of non-small cell lung carcinoma (NSCLC) cells succumbing to cisplatin (cis-diamminedichloroplatinum(II), CDDP). Accordingly, pyridoxine promoted the antineoplastic activity of CDDP in NSCLC-bearing mice only in the presence of an intact immune system. These findings may have implications for the development of novel strategies to circumvent CDDP resistance.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.