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Abstract Title:

Prescription consisting of Vitamin C and Baicalin inhibits tumor growth by enhancing the antioxidant capacity in vivo.

Abstract Source:

J BUON. 2015 Sep-Oct;20(5):1368-72. PMID: 26537087

Abstract Author(s):

Kun Li, Jie Wang, Ming Shi, Jian Li, Li Yan, Haizhao Zhang, Chengbiao Lu

Article Affiliation:

Kun Li

Abstract:

PURPOSE: To explore the antitumor effect of prescription consisting of Vitamin C (Vc) and Baicalin (PVB).

METHODS: To explore the antitumor effect of PVB, using U14 cervical tumor-bearing mice model was used and the drugs were administrated through the gavages. Spectrophotometry was used to determine the content of superoxide dismutase (SOD), malondialdehyde (MDA) and cytokines IL-2, Il-4 and IFN-γ.

RESULTS: PVB had a better antitumor effect than baicalin and Vc used alone with an inhibition rate of 58.18% (p<0.05); PVB significantly improved the spleen index (p<0.01), and significantly reduced MDA content (p<0.01) but increased SOD activity in liver tissue and serum (p<0.01).

CONCLUSIONS: PVB shows better antitumor effect than Vc and baicalin used alone, and it can significantly enhance the immunity and antioxidant capacity of the mice.

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Sayer Ji
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