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Abstract Title:

Vitamin C improves liver and renal functions in hypothyroid rats by reducing tissue oxidative injury.

Abstract Source:

Int J Vitam Nutr Res. 2019 Feb 21:1-11. Epub 2019 Feb 21. PMID: 30789800

Abstract Author(s):

Mahdi Esmaeilizadeh, Mahmoud Hosseini, Farimah Beheshti, Vajihe Alikhani, Zakieh Keshavarzi, Mohsen Shoja, Mozhgan Mansoorian, Hamid Reza Sadeghnia

Article Affiliation:

Mahdi Esmaeilizadeh

Abstract:

BACKGROUND: The effects of Vit C on liver and renal function and the tissues oxidative damage was investigated in hypothyroid rats.

MATERIALS AND METHODS: The pregnant rats were divided into 5 groups (n=6): (1) Control; (2) Propylthiouracil (PTU; 0.005%), (3-5) PTU plus 10, 100 or 500 mg/kg b.w. Vit C. The drugs were added to the drinking water of the dams and their pups during lactation period and then continued for the offspring through thefirst 8 weeks of their life. Finally, 7 male offspring from each group were randomly selected.

RESULTS: Thyroxine, protein and albumin concentrations in the serum and thiol content and superoxide dismutase (SOD) and catalase (CAT) activities in renal and liver tissues of hypothyroid group was lower (all P<0.001) while, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALK-P), creatinine and blood urea nitrogen (BUN) concentrations in the serum and malondialdehyde (MDA) in the liver and renal tissues were higher than the control (all P<0.001). All doses of Vit C increased thyroxine, protein and albumin and thiol content in in renal and liver tissues while, decreased AST, ALT and ALK-P concentration and MDA in liver and renal tissues compared to PTU group (P<0.05-P<0.001). Creatinine, BUN and SOD and CAT were improved by both 100 and 500 mg/kg of Vit C in the renal (P<0.05-P<0.001) and by 100 mg/kg in the liver (P<0.05-P<0.001).

CONCLUSION: Vit C improved liver and renal function of hypothyroid rats which might be due to its protective effects against tissues oxidative damage.

Study Type : Animal Study

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