Abstract Title:

[Ascorbic acid level and the indicators of cellular immunity in patients with hepatitis A during pathogenetic therapy].

Abstract Source:

Vopr Pitan. 1988 Jul-Aug(4):31-4. PMID: 3266046

Abstract Author(s):

V S Vasil'ev, V I Komar


Ascorbic acid content was assayed in plasma and neutrophils of peripheral blood in 260 patients with virus hepatitis A during acute period of the disease. The data obtained have evidenced C-hypovitaminosis in these patients, that was more pronounced in the winter-spring period, according to the disease severity 300 mg of ascorbic acid for 1.5 g of galascorbin/day have proved to be the most optimal dose for vitamin C deficiency elimination. A significant decrease in T-lymphocyte level and an increase in 0-cell content were recorded in the acute period of virus hepatitis A. Ascorbic acid drugs promoted more rapid recovery of T-lymphocyte content in the peripheral blood that has confirmed the necessity of vitamin C administration in combined pathogenetic therapy of patients with virus hepatitis A.

Study Type : Human Study
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