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Article Publish Status: FREE
Abstract Title:

Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study.

Abstract Source:

Nutrients. 2017 Aug 3 ;9(8). Epub 2017 Aug 3. PMID: 28771190

Abstract Author(s):

John F Pearson, Juliet M Pullar, Renee Wilson, Janet K Spittlehouse, Margreet C M Vissers, Paula M L Skidmore, Jinny Willis, Vicky A Cameron, Anitra C Carr

Article Affiliation:

John F Pearson

Abstract:

A cohort of 50-year-olds from Canterbury, New Zealand (N = 404), representative of midlife adults, undertook comprehensive health and dietary assessments. Fasting plasma vitamin C concentrations (N = 369) and dietary vitamin C intake (N = 250) were determined. The mean plasma vitamin C concentration was 44.2µmol/L (95% CI 42.4, 46.0); 62% of the cohort had inadequate plasma vitamin C concentrations (i.e.,<50µmol/L), 13% of the cohort had hypovitaminosis C (i.e.,<23µmol/L), and 2.4% had plasma vitamin C concentrations indicating deficiency (i.e.,<11µmol/L). Men had a lower mean plasma vitamin C concentration than women, and a higher percentage of vitamin C inadequacy and deficiency. A higher prevalence of hypovitaminosis C and deficiency was observed in those of lower socio-economic status and in current smokers. Adults with higher vitamin Clevels exhibited lower weight, BMI and waist circumference, and better measures of metabolic health, including HbA1c, insulin and triglycerides, all risk factors for type 2 diabetes. Lower levels of mild cognitive impairment were observed in those with the highest plasma vitamin C concentrations. Plasma vitamin C showed a stronger correlation with markers of metabolic health and cognitive impairment than dietary vitamin C.

Study Type : Human Study

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