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Article Publish Status: FREE
Abstract Title:

Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity.

Abstract Source:

J Cell Physiol. 2012 Sep ;227(9):3216-24. PMID: 22105792

Abstract Author(s):

Fulan Wei, Cunye Qu, Tieli Song, Gang Ding, Zhipeng Fan, Dayong Liu, Yi Liu, Chunmei Zhang, Songtao Shi, Songlin Wang

Article Affiliation:

Fulan Wei

Abstract:

Cell sheet engineering has been developed as an alternative approach to improve mesenchymal stem cell-mediated tissue regeneration. In this study, we found that vitamin C (Vc) was capable of inducing telomerase activity in periodontal ligament stem cells (PDLSCs), leading to the up-regulated expression of extracellular matrix type I collagen, fibronectin, and integrinβ1, stem cell markers Oct4, Sox2, and Nanog as well as osteogenic markers RUNX2, ALP, OCN. Under Vc treatment, PDLSCs can form cell sheet structures because of increased cell matrix production. Interestingly, PDLSC sheets demonstrated a significant improvement in tissue regeneration compared with untreated control dissociated PDLSCs and offered an effective treatment for periodontal defects in a swine model. In addition, bone marrow mesenchymal stem cell sheets and umbilical cord mesenchymal stem cell sheets were also well constructed using this method. The development of Vc-mediated mesenchymal stem cell sheets may provide an easy and practical approach for cell-based tissue regeneration.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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