Article Publish Status: FREE
Abstract Title:

Vitamin D and depression: mechanisms, determination and application.

Abstract Source:

Asia Pac J Clin Nutr. 2019 ;28(4):689-694. PMID: 31826364

Abstract Author(s):

Chunmei Geng, Abdul Sami Shaikh, Wenxiu Han, Dan Chen, Yujin Guo, Pei Jiang

Article Affiliation:

Chunmei Geng


Depression is the most common debilitating psychiatric disease, the pathological mechanisms of which are associated with multiple aspects of neural function. While recent evidence has consistently suggested that a suboptimal vitamin D status is frequently observed in patients with depression, the results concerning whether vitamin D insufficiency is a causal factor of depression or is secondary to depressive behavior are conflicting; additionally, the lack of consistency of the method of vitamin D determination between labs has further worsened this confusion. Herein, we reviewed the neuroactivities of vitamin D that may be associated with depression and the current studies and clinical investigations to provide a full overview on the use of vitamin D in the treatment and prevention of depression.

Study Type : Review

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Sayer Ji
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