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Article Publish Status: FREE
Abstract Title:

Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis.

Abstract Source:

J Pharmacol Pharmacother. 2012 Oct ;3(4):300-3. PMID: 23326099

Abstract Author(s):

Jaykaran Charan, Jagdish P Goyal, Deepak Saxena, Preeti Yadav

Article Affiliation:

Jaykaran Charan

Abstract:

OBJECTIVES: To explore the effect of vitamin D supplementation in prevention of respiratory tract infections on the basis of published clinical trials.

MATERIALS AND METHODS: Clinical trials were searched from various electronic databases. Five clinical trials were suitable for inclusion. Outcome was events of respiratory tract infections in vitamin D group and placebo group. Data was reported as odds ratio with 95% confidence interval. Both random and fixed model was used for analysis. Analysis was done with the help of Comprehensive meta-analysis software 2.

RESULTS: Events of respiratory tract infections were significantly lower in vitamin D group as compared to control group [Odds ratio = 0.582 (0.417 - 0.812) P = 0.001] according to random model. Results were similar in fixed model. On separate analysis of clinical trials dealing with groups of children and adults, beneficial effect of vitamin D was observed in both, according to fixed model [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.653 (0.472 - 0.9040, P = 0.010 respectively]. On using random model beneficial effect persisted in children's group but became nonsignificant in adults group [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.544 (0.278 - 1.063) P = 0.075 respectively].

CONCLUSION: Vitamin D supplementation decreases the events related to respiratory tract infections. There is need of more well conducted clinical trials to reach to a certain conclusion.

Study Type : Meta Analysis
Additional Links
Pharmacological Actions : Immunomodulatory : CK(2249) : AC(733)
Additional Keywords : vaccine alternatives
Anti Therapeutic Actions : Vaccination: All : CK(6351) : AC(662)

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