Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American children.
Obesity (Silver Spring). 2008 Jan;16(1):90-5. PMID: 18223618
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Kumaravel.Rajakumar@chp.edu
BACKGROUND: Serum 25-hydroxyvitamin D (25(OH)D) is low in obese adults. OBJECTIVE: To examine serum 25(OH)D in obese (BMI>95th percentile for age) vs. non-obese (BMI = 5th-75th percentile for age) 6-10-year-old African American children and compare their differences in therapeutic response to vitamin D supplementation. METHODS AND PROCEDURES: In an open label non-randomized pre-post comparison 21 obese (OB) and 20 non-obese (non-OB) subjects matched for age, sex, skin color, and pubertal maturation were treated with 400 IU of vitamin D(3) daily for 1 month. Serum 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D), parathyroid hormone (PTH), leptin, and markers of bone turnover (serum bone-specific alkaline phosphatase (BSAP), osteocalcin (OC), and urine n -telopeptide cross-links of type 1 collagen (urine NTX)) were measured. Vitamin D deficiency was defined as serum 25(OH)D