Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with Type 2 diabetes.
Diabetes Metab Res Rev. 2016 May 7. Epub 2016 May 7. PMID: 27155442
BACKGROUND: Vitamin D deficiency (VDD) was reported to be associated with diabetic peripheral neuropathy (DPN). But the association in Chinese population and the screening value of VDD for DPN were unknown.
METHODS: A total of 861 patients with type 2 diabetes were recruited in this cross-sectional study. VDD was defined as serum circulating 25-hydroxyvitamin D(25(OH)D) level < 20 ng/mL. DPN was evaluated by neurological symptoms, neurological signs, neurothesiometer, and electromyogram.
RESULTS: The patients with DPN had significantly lower serum 25(OH)D concentration (15.59 ± 7.68 ng/mL) and higher prevalence of VDD (80%) than patients with signs of DPN (17.66 ± 7.50 ng/mL; 64.5%) and non-DPN patients (18.35 ± 6.60; 61.7%) (all p < 0.01). Spearman's correlation analysis showed that serum circulating 25(OH)D level was closely associated with DPN (r = 0.121) and sings of DPN (r = 0.111) (both p<0.01). After adjusting for all potential confounders, VDD was still linked with increased risk of DPN [odds ratio (OR) 2.59 (1.48-4.53)] (p<0.01). Logistical regression analysis further revealed that VDD was an independent risk factor for DPN ( = 0.88) (p<0.01). ROC analysis indicated that serum 25(OH)D<17.22 ng/mL hinted the signs of DPN and serum 25(OH)D<16.01 ng/ml predicted the occurrence of DPN (both p<0.01).
CONCLUSIONS: VDD is an independent risk factor for DPN and may be a potential biomarker for DPN in Chinese patients with Type 2 diabetes.