Abstract Title:

Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with Type 2 diabetes.

Abstract Source:

Diabetes Metab Res Rev. 2016 May 7. Epub 2016 May 7. PMID: 27155442

Abstract Author(s):

Rui He, Yanyun Hu, Hui Zeng, Jun Zhao, Jungong Zhao, Yimin Chai, Fengdi Lu, Fang Liu, Weiping Jia

Article Affiliation:

Rui He


BACKGROUND: Vitamin D deficiency (VDD) was reported to be associated with diabetic peripheral neuropathy (DPN). But the association in Chinese population and the screening value of VDD for DPN were unknown.

METHODS: A total of 861 patients with type 2 diabetes were recruited in this cross-sectional study. VDD was defined as serum circulating 25-hydroxyvitamin D(25(OH)D) level < 20 ng/mL. DPN was evaluated by neurological symptoms, neurological signs, neurothesiometer, and electromyogram.

RESULTS: The patients with DPN had significantly lower serum 25(OH)D concentration (15.59 ± 7.68 ng/mL) and higher prevalence of VDD (80%) than patients with signs of DPN (17.66 ± 7.50 ng/mL; 64.5%) and non-DPN patients (18.35 ± 6.60; 61.7%) (all p < 0.01). Spearman's correlation analysis showed that serum circulating 25(OH)D level was closely associated with DPN (r = 0.121) and sings of DPN (r = 0.111) (both p<0.01). After adjusting for all potential confounders, VDD was still linked with increased risk of DPN [odds ratio (OR) 2.59 (1.48-4.53)] (p<0.01). Logistical regression analysis further revealed that VDD was an independent risk factor for DPN ( = 0.88) (p<0.01). ROC analysis indicated that serum 25(OH)D<17.22 ng/mL hinted the signs of DPN and serum 25(OH)D<16.01 ng/ml predicted the occurrence of DPN (both p<0.01).

CONCLUSIONS: VDD is an independent risk factor for DPN and may be a potential biomarker for DPN in Chinese patients with Type 2 diabetes.

Study Type : Human Study

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.