Article Publish Status: FREE
Abstract Title:

Comparison of Vitamin D Levels in Patients with and without Acne: A Case-Control Study Combined with a Randomized Controlled Trial.

Abstract Source:

PLoS One. 2016 ;11(8):e0161162. Epub 2016 Aug 25. PMID: 27560161

Abstract Author(s):

Seul-Ki Lim, Jeong-Min Ha, Young-Ho Lee, Young Lee, Young-Joon Seo, Chang-Deok Kim, Jeung-Hoon Lee, Myung Im

Article Affiliation:

Seul-Ki Lim


BACKGROUND: Vitamin D plays an important role in the immune system, and its deficiency has been implicated in various skin diseases, including atopic dermatitis and psoriasis. Acne is a common inflammatory skin disease; however, the association with vitamin D remains unclear.

OBJECTIVES: We evaluated vitamin D levels in patients with acne to determine the effect of vitamin D supplementation.

METHODS: This study included 80 patients with acne and 80 healthy controls. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured, and demographic data were collected. Vitamin D-deficient patients were treated with oral cholecalciferol at 1000 IU/day for 2 months.

RESULTS: Deficiency in 25(OH)D was detected in 48.8% of patients with acne, but in only 22.5% of the healthy controls. The level of 25(OH)D was inversely associated with the severity of acne, and there was a significant negative correlation with inflammatory lesions. In a subsequent trial, improvement in inflammatory lesions was noted after supplementation with vitamin D in 39 acne patients with 25(OH)D deficiency.

LIMITATIONS: Limitations of the study include the small number of patients in the supplementation study and the natural fluctuation of acne.

CONCLUSIONS: Vitamin D deficiency was more frequent in patients with acne, and serum 25(OH)D levels were inversely correlated with acne severity, especially in patients with inflammatory lesions.

Study Type : Human Study

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