Abstract Title:

Vitamin D and colon cancer.

Abstract Source:

Endocr Relat Cancer. 2012 Mar 1. Epub 2012 Mar 1. PMID: 22383428

Abstract Author(s):

Fábio Pereira, María Jesús Larriba, Alberto Muñoz

Article Affiliation:

F Pereira, Cancer Biology, Instituto de Investigaciones Biomédicas"Alberto Sols", Madrid, Spain.

Abstract:

The most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), is a pleiotropic hormone with wide regulatory actions. Classically, vitamin D deficiency was known to alter calcium and phosphate metabolism and bone biology. In addition, recent epidemiological and experimental studies support the association of vitamin D deficiency with a large variety of human diseases, and particularly with the high risk of colorectal cancer. By regulating the expression of many genes via several mechanisms, 1,25(OH)2D3 induces differentiation, controls the detoxification metabolism and cell phenotype, sensitizes cells to apoptosis, and inhibits the proliferation of cultured human colon carcinoma cells. Consistently, 1,25(OH)2D3 and several of its analogues decrease intestinal tumourigenesis in animal models. Molecular, genetic, and clinical data in humans are scarce but they suggest that vitamin D is protective against colon cancer. Clearly, the available evidence warrants new, well-designed, large-scale trials to clarify the role of vitamin D in the prevention and/or therapy of this important neoplasia.

Study Type : Review

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