Liposomal Vitamin Das an Anti-aging Agent for the Skin.
Pharmaceutics. 2019 Jul 3 ;11(7). Epub 2019 Jul 3. PMID: 31277236
Vitamin Dis an effective skin protective substance to prevent photoaging. Liposomes were used as a carrier to deliver vitamin Dto improve the stability and to enhance the treatment effect of vitamin D. The stability of vitamin Dliposomes, average cumulative penetration, and retention of vitamin Din the skin were then evaluated and compared with free vitamin D. Finally, the treatment effect of vitamin Dliposomes in a rat photoaging model was appraised and Haematoxylin-Eosin (H&E) staining was used to assess the histology changes of the skin after vitamin Dliposome treatment. The results indicated that liposomes could significantly improve the stability of vitamin D. The average skin retention of vitamin Dliposomes was 1.65 times that of the vitamin Dsolution. Vitamin Dliposomes could repair the surface morphology of skin in the photoaging model and promote the production of new collagen fibers. Vitamin Dliposomes as a potential skin care agent could significantly improve skin appearance and repair damage in the histology of photoaging.