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Abstract Title:

Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.

Abstract Source:

J Dermatolog Treat. 2010 Jul 24. Epub 2010 Jul 24. PMID: 20653487

Abstract Author(s):

Mohammad Hassan Javanbakht, Seyed Ali Keshavarz, Mahmoud Djalali, Fereydoun Siassi, Mohammad Reza Eshraghian, Alireza Firooz, Hassan Seirafi, Amir Hooshang Ehsani, Maryam Chamari, Abbas Mirshafiey

Article Affiliation:

Department of Nutrition and Biochemistry, Faculty of Public Health.

Abstract:

Abstract Background: Atopic dermatitis is a chronically relapsing, highly pruritic and inflammatory skin disease. This study was done to assess the effects of vitamins D and E supplementation on the clinical manifestation of atopic dermatitis. Methods: Forty-five atopic dermatitis patients were included in a randomized, double-blind, placebo-controlled trial. They were randomly divided into four groups and treated for 60 days: group P (n = 11), vitamins D and E placebos; group D (n = 12), 1600 IU vitamin D(3) plus vitamin E placebo; group E (n = 11), 600 IU synthetic all-rac-alpha-tocopherol plus vitamin D placebo; and group DE (n = 11), 1600 IU vitamin D(3) plus 600 IU synthetic all-rac-alpha-tocopherol. Serum 25(OH) vitamin D and plasma alpha-tocopherol were determined before and after the trial. The clinical improvement was evaluated with SCORing Atopic Dermatitis (SCORAD). Data were analyzed by analysis of variance (ANOVA) and Kruskal-Wallis tests. Results: SCORAD was reduced after 60 days in groups D, E and DE by 34.8%, 35.7% and 64.3%, respectively (p = 0.004). Objective SCORAD also showed significant improvement. There was a positive correlation between SCORAD and intensity, objective, subjective and extent (p<0.001). We found a significant negative association between plasma alpha-tocopherol and SCORAD, intensity, objective and extent (p = 0.02). Conclusion: This study supports the contributing and beneficial effects of vitamins D and E in the treatment of atopic dermatitis.

Study Type : Human Study

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