Vitamin K2 has immunomodulatory activities. - GreenMedInfo Summary
Immunomodulatory effect of vitamin K2: Implications for bone health.
Oral Dis. 2018 Mar ;24(1-2):67-71. PMID: 29480629
V D Myneni
OBJECTIVE: In women with postmenopausal osteoporosis, vitamin K2 appears to decrease the incidence of hip, vertebral, and non-vertebral fractures. Women with postmenopausal osteoporosis have more circulating activated T cells compared with healthy postmenopausal and premenopausal women, but the effects of vitamin K2 on T cells have not been studied. In this study, we have looked at T-cell suppression by vitamin K2.
MATERIALS AND METHODS: Peripheral blood mononuclear cells (PBMCs) from three healthy donors were used. The PBMCs were stimulated with the mitogens phytohemagglutinin and concanavalin A, and T-cell proliferation was analyzed using flow cytometry based on carboxyfluorescein succinimidyl ester (CSFE) dye dilution.
RESULTS: Vitamin K2 (60 and 100 μM) inhibited T-cell proliferation. Vitamin K1 at the same concentrations did not inhibit T-cell proliferation.
CONCLUSION: Vitamin K2 has immunomodulatory activities.