Abstract Title:

Immunomodulatory effect of vitamin K2: Implications for bone health.

Abstract Source:

Oral Dis. 2018 Mar ;24(1-2):67-71. PMID: 29480629

Abstract Author(s):

V D Myneni, E Mezey

Article Affiliation:

V D Myneni


OBJECTIVE: In women with postmenopausal osteoporosis, vitamin K2 appears to decrease the incidence of hip, vertebral, and non-vertebral fractures. Women with postmenopausal osteoporosis have more circulating activated T cells compared with healthy postmenopausal and premenopausal women, but the effects of vitamin K2 on T cells have not been studied. In this study, we have looked at T-cell suppression by vitamin K2.

MATERIALS AND METHODS: Peripheral blood mononuclear cells (PBMCs) from three healthy donors were used. The PBMCs were stimulated with the mitogens phytohemagglutinin and concanavalin A, and T-cell proliferation was analyzed using flow cytometry based on carboxyfluorescein succinimidyl ester (CSFE) dye dilution.

RESULTS: Vitamin K2 (60 and 100 μM) inhibited T-cell proliferation. Vitamin K1 at the same concentrations did not inhibit T-cell proliferation.

CONCLUSION: Vitamin K2 has immunomodulatory activities.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(2249) : AC(733)

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