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Article Publish Status: FREE
Abstract Title:

Vitamin K2 Prevents Lymphoma in Drosophila.

Abstract Source:

Sci Rep. 2017 Dec 6 ;7(1):17047. Epub 2017 Dec 6. PMID: 29213118

Abstract Author(s):

Maytham A Dragh, Zhiliang Xu, Zainab S Al-Allak, Ling Hong

Article Affiliation:

Maytham A Dragh

Abstract:

Previous studies have established the anticancer effect of vitamin K2 (VK2). However, its effect on lymphoma induced by UBIAD1/heix mutation in Drosophila remains unknown. Therefore, we aimed to develop an in vivo model of lymphoma for the precise characterization of lymphoma phenotypes. We also aimed to improve the understanding of the mechanisms that underlie the preventative effects of VK2 on lymphoma. Our results demonstrated that VK2 prevents lymphoma by acting as an electron carrier and by correcting the function and structure of mitochondria by inhibiting mitochondrial reactive oxygen species production mtROS. Our work identifies mitochondria as a key player in cancer therapy strategies.

Study Type : Insect Study
Additional Links
Pharmacological Actions : Chemopreventive : CK(4220) : AC(1326)

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