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Abstract Title:

In vitro anti-tumor activity of the tanshinone IIA against SKOV3 cells.

Abstract Source:

Nat Prod Res. 2016 Aug ;30(16):1844-6. Epub 2015 Aug 7. PMID: 26252372

Abstract Author(s):

Ju Huang, Hao Lin, YingKai Hong

Article Affiliation:

Ju Huang

Abstract:

The aim of this study was to determine the anti-tumour activity of tanshinone IIA in SKOV3 cells. Results suggested that tanshinone IIA could significantly inhibit (IC50 value  =  19.6 μM) the proliferation and induce apoptosis of SKOV3 cells as demonstrated by flow cytometry analysis. In addition, tanshinone IIA treatment induced G2/M phase cell cycle arrest in SKOV3 cells. The results of Western blotting indicated that tanshinone IIA can suppress the expressionof anti-apoptotic protein Bcl-2, increase (0.28 vs. 0.62) the expression of pro-apoptotic protein Bax (0.83 vs. 0.24) in SKOV3 cells. It can be concluded that the tanshinone IIA may be a possible therapeutic candidate having cytotoxic and anti-tumour potential.

Study Type : In Vitro Study

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