In Vitro Anticancer and Radiosensitizing Activities of Phlorethols from the Brown Alga.
Molecules. 2020 Jul 14 ;25(14). Epub 2020 Jul 14. PMID: 32674415
Olesya S Malyarenko
The anticancer and radiosensitizing effects of high-molecular-weight phlorethols(Mw = 2520 Da) isolated from the brown algae ofon human colorectal carcinoma HCT 116 and HT-29 cells were investigated. Phloretholspossessed cytotoxic activity against HT-29 (IC= 92μg/mL) and HCT 116 (IC= 94μg/mL) cells.at non-toxic concentrations inhibited the colony formation in colon cancer cells and significantly enhanced their sensitivity to low non-toxic X-ray irradiation. The combinatory effect of radiation andwas synergistic (Combination index<0.7). Algal phlorethols might be prospective candidates as radiosensitizers to improve the scheme of radiotherapy.