n/a
Article Publish Status: FREE
Abstract Title:

In Vitro Anticancer and Radiosensitizing Activities of Phlorethols from the Brown Alga.

Abstract Source:

Molecules. 2020 Jul 14 ;25(14). Epub 2020 Jul 14. PMID: 32674415

Abstract Author(s):

Olesya S Malyarenko, Tatiana I Imbs, Svetlana P Ermakova

Article Affiliation:

Olesya S Malyarenko

Abstract:

The anticancer and radiosensitizing effects of high-molecular-weight phlorethols(Mw = 2520 Da) isolated from the brown algae ofon human colorectal carcinoma HCT 116 and HT-29 cells were investigated. Phloretholspossessed cytotoxic activity against HT-29 (IC= 92μg/mL) and HCT 116 (IC= 94μg/mL) cells.at non-toxic concentrations inhibited the colony formation in colon cancer cells and significantly enhanced their sensitivity to low non-toxic X-ray irradiation. The combinatory effect of radiation andwas synergistic (Combination index<0.7). Algal phlorethols might be prospective candidates as radiosensitizers to improve the scheme of radiotherapy.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.