Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

n/a
Article Publish Status: FREE
Abstract Title:

antioxidant activity of olive leaf extract (L.) and its protective effect on oxidative damage in human erythrocytes.

Abstract Source:

Heliyon. 2018 Sep ;4(9):e00805. Epub 2018 Sep 20. PMID: 30255162

Abstract Author(s):

Patricia Goldschmidt Lins, Silvana Marina Piccoli Pugine, Antonio Márcio Scatolini, Mariza Pires de Melo

Article Affiliation:

Patricia Goldschmidt Lins

Abstract:

Aims: This study aimed to evaluateantioxidant capacity of olive leaf extract (OLE),L., and its protective effect on peroxyl radical-induced oxidative damage in human erythrocytes.

Main methods: The OLE was evaluated by the following assays: i) total phenolic and flavonoid content; ii) oleuropein content; iii) Ferric reducing antioxidant power (FRAP); iv) antioxidant activity against ABTS, DPPHand reactive oxygen and nitrogen species: superoxide anion (), hypochlorous acid (HOCl) and nitric oxide (NO) and v) protective effect on peroxyl radical-induced oxidative damages in human erythrocytes as hemolysis, thiobarbituric acid reactive substances (TBARS) formation and oxyhemoglobin oxidation.

Key findings: Total phenolic and flavonoid contents were 131.7± 9.4 mg gallic acid equivalents/g dry weight (dw) and 19.4 ± 1.3 mg quercetin equivalents/g dw, respectively. Oleuropein content was 25.5 ± 5.2 mg/g dw. FRAP analysis was 281.8 ± 22.8 mg trolox equivalent/g dw and OLE inhibited ABTS(50% effective concentration (EC) = 16.1± 1.2 μg/mL) and DPPH(EC= 13.8± 0.8 μg/mL). The extract demonstrated effective ability to scavenge (EC= 52.6± 2.1 μg/mL), NO(EC= 48.4± 6.8 μg/mL) and HOCl (EC= 714.1± 31.4 μg/mL). The extract inhibited peroxyl radical-induced hemolysis (EC= 11.5± 1.5 μg/mL), TBARS formation (EC= 38.0± 11.7 μg/mL) and hemoglobin oxidation (EC= 186.3± 29.7 μg/mL) in erythrocytes.

Significance: OLE is an important source of natural antioxidants; it has effective antioxidant activity against different reactive species and protects human erythrocytes against oxidative damage.

Study Type : In Vitro Study

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.