In vitro antioxidant and cancer inhibitory activity of a colored avocado seed extract. - GreenMedInfo Summary
In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract.
Int J Food Sci. 2019 ;2019:6509421. Epub 2019 Apr 24. PMID: 31179313
Avocado () seeds have been used traditionally for a number of health-related indications. Because of its high polyphenol content, we investigated the potential antioxidant and anticancer effects of a colored avocado seed extract (CASE). CASE exhibited an oxygen radical acceptance capacity value of 2012± 300 trolox equivalents/mg. CASE reduced lipid hydroperoxide formation in an oil-in-water emulsion (33% reduction at 500g/mL). CASE dose-dependently reduced the viability of human breast (MCF7), lung (H1299), colon (HT29), and prostate (LNCaP) cancer cells. The half maximal inhibitory concentrations ranged from 19 to 132g/mL after treatment for 48 h. CASE treatment downregulated the expression of cyclin Dand Ein LNCaP cells. This was associated with cell G/Gphase cycle arrest. CASE also dose-dependently induced apoptosis in LNCaP cells. CASE reduced nuclear translocation of nuclear factorB, a prosurvival signal. Further studies are needed to examine these effects inmodels.