In vitro evaluation of Lavandula angustifolia essential oil on anti- toxoplasma activity. - GreenMedInfo Summary
Evaluation ofEssential Oil on Anti-Activity.
Front Cell Infect Microbiol. 2021 ;11:755715. Epub 2021 Sep 29. PMID: 34660350
The current methods of treating toxoplasmosis have a number of side effects, and these therapies are only effective against the acute stage of the disease. Thus, development of new low toxicity and efficient anti-drugs is extremely important. Natural products are important sources for screening new drugs; among them, essential oils (EOs) have efficacy in anti-bacterial, anti-inflammatory, anti-insect, and other aspects. In this study, 16 EOs were screened for their anti-activity.essential oil (EO)was found to have an anti-parasitic effect on. The cytotoxicity ofEO was firstly evaluated using the MTT assay on human foreskin fibroblast (HFF) cells, and then the anti-activity was evaluated by plaque assay. Finally, the invasion experiment and electron microscope observation were used to study the mechanism ofEO in anti-toxoplasma activity. The results indicated that the CCofEO was 4.48 mg/ml and thatEO had activity againstand the inhibition was in a dose-dependent manner under safe concentrations.EO was able to reduceinvasion, which may be due to its detrimental effect on changes of the morphology of tachyzoites. These findings indicated thatEO could be a potential drug for treating toxoplasmosis.