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Abstract Title:

osteogenic activities of sulfated derivative of polysaccharide extracted fromL.

Abstract Source:

Biol Chem. 2021 Aug 2. Epub 2021 Aug 2. PMID: 34342947

Abstract Author(s):

Minh Thi Hong Nguyen, Chien Van Tran, Phuong Hong Nguyen, Quang De Tran, Min-Sung Kim, Won-Kyo Jung, Phuong Thi Mai Nguyen

Article Affiliation:

Minh Thi Hong Nguyen

Abstract:

Osteoporosis, one of the most serious public health concerns caused by an imbalance between bone resorption and bone formation, has a major impact on the population. Therefore, finding the effective osteogenic compounds for the treatment of osteoporosis is a promising research approach. In our study, tamarind (L.) seed polysaccharide (TSP) extracted from tamarind seed was subjected to synthesize its sulfate derivatives. TheH NMR, FT-IR, SEM, monosaccharide compositions and elemental analysis data revealed that tamarind seed polysaccharide sulfate (TSPS) was successfully prepared. As the result, TSPS showed potent effects on inducing osteoblast differentiation via increasing alkaline phosphatase (ALP) activity up to 20% after 10 days and bone mineralization approximately 58% after four weeks at concentration of 20 μg/mL, whereas no statistically increase for both ALP activity and bone mineralization was observed in TSP treatment. Furthermore, TSPS enhanced expression of several marker genes in bone formation. Overall, the obtained data provided novelty on osteogenic compounds originated from TSP of, as well as scientific fundamentals on drug development and bone tissue engineering for the treatment of osteoporosis and other bone-related diseases.

Study Type : In Vitro Study
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