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Abstract Title:

Anticancer potential of ginger: mechanistic and pharmaceutical aspects.

Abstract Source:

Curr Pharm Des. 2016 Jun 8. Epub 2016 Jun 8. PMID: 27290916

Abstract Author(s):

Indu Pal Kaur, Parneet Kaur Deol, Kanthi Kiran, Mahendra Bishnoi

Article Affiliation:

Indu Pal Kaur

Abstract:

Multifaceted pathologies like cancers involve multiple targets. Failure of current treatment options modulating specific tumor target, evokes need for alternate approach of either combining several smart drugs or design a dirty drug that may simultaneously influence multiple targets to trigger a cascade of protective events complementing one another. Ginger exhibits a pleiotropy of antioxidant, anti-inflammatory, antiemetic, anticancer, and antimutagenic effects. In vivo and in vitro studies have established that phenolic components of ginger, particularly 6-gingerol and 6-shogaol induce apoptosis and autophagy and inhibit metastasis. Present review tends to unravel the mechanism of anticancer action of ginger and also address issues, which may limit its realization as a biotherapeutic.

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Sayer Ji
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