Article Publish Status: FREE
Abstract Title:

In Vivo Antidepressant Effect off.into Cationic Nanoparticles: Improving Bioactivity and Safety.

Abstract Source:

Pharmaceutics. 2020 Apr 21 ;12(4). Epub 2020 Apr 21. PMID: 32326277

Abstract Author(s):

Jovelina Samara Ferreira Alves, Alaine Maria Dos Santos Silva, Rodrigo Moreira da Silva, Pamella Rebeca Fernandes Tiago, Thais Gomes de Carvalho, Raimundo Fernandes de Araújo Júnior, Eduardo Pereira de Azevedo, Norberto Peporine Lopes, Leandro De Santis Ferreira, Elaine Cristina Gavioli, Arnóbio Antônio da Silva-Júnior, Silvana Maria Zucolotto

Article Affiliation:

Jovelina Samara Ferreira Alves


A variety of neuroactive flavonoids can be found in the species of thegenus; however, their difficulty in crossing the blood-brain barrier limits their in vivo neuropharmacological activity. In this study, cationic nanoparticles were developed as a novel nanocarrier for improving the antidepressant activity off.leaf extract. Formulations obtained using Eudragit E PO polymethylmethacrylate copolymer, as polymeric matrix had their physicochemical properties investigated. The analytical content of the flavonoids vicenin-2, orientin, isoorientin, vitexin, and isovitexin was determined in the plant extract. Small-sized and spherical nanoparticles loaded withf.were obtained with positive zeta potential and high encapsulation efficiency. In addition, the nanosystems were shown to be stable for at least 6 months. The antidepressant activity ofextract (50 and 100 mg/kg) as well as the extract-loaded nanoparticles (5 mg/kg) were investigated in mice using the forced swimming test, where the latter increased the potency of the former by 10-fold. In addition, histopathological and biochemical analysis confirmed the biocompatibility of the extract-loaded nanoparticles. This study demonstrated that the Eudragit cationic nanoparticles were able to improve the antidepressant activity ofin the central nervous system of mice.

Study Type : Animal Study

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