Abstract Title:

Vitamin E protects against the development of radiation-induced pulmonary fibrosis in rats.

Abstract Source:

Clin Oncol (R Coll Radiol). 2007 May;19(4):260-4. Epub 2007 Jan 12. PMID: 17433970

Abstract Author(s):

N S Bese, F Munzuroglu, B Uslu, S Arbak, G Yesiladali, N Sut, T Altug, A Ober


AIMS: To investigate whether the application of vitamin E with or without pentoxifylline could modify the development of radiation-induced pulmonary fibrosis. MATERIALS AND METHODS: Wistar albino rats were supplemented with either vitamin E or pentoxifylline or with both vitamin E and pentoxifylline after a single dose of 14 Gy thoracic irradiation. Supplementation was started the day after irradiation and continued until the rats were sacrificed. As a quantitative end point, the extent of fibrosis was evaluated with a scale from 0 (normal lung) to 8 (total fibrous obliteration of the field) at pathological examination of the lung tissue. RESULTS: A significant reduction in fibrosis was obtained in the group of rats supplemented with vitamin E with or without pentoxifylline, when compared with the group that had irradiation only. CONCLUSION: This experimental study showed that vitamin E supplementation immediately after irradiation protected rats against radiation-induced pulmonary fibrosis. The combination with pentoxifylline was more effective, although pentoxifylline itself had limited efficacy, which was not statistically significant.

Study Type : Animal Study

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