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Article Publish Status: FREE
Abstract Title:

Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells.

Abstract Source:

Eur J Nutr. 2012 Aug ;51(5):563-72. Epub 2011 Aug 24. PMID: 21863241

Abstract Author(s):

D Zapolska-Downar, D Bryk, M Małecki, K Hajdukiewicz, D Sitkiewicz

Article Affiliation:

D Zapolska-Downar

Abstract:

BACKGROUND: Altered expression of cell adhesion molecules (CAMs) has been implicated in a variety of chronic inflammatory conditions, including atherosclerosis. Regulation of adhesion molecule expression by specific redox-sensitive mechanisms has been reported. Additionally, it has been observed that the extract of Aronia melanocarpa (A. Melanocarpa) fruits, rich in polyphenols, exhibits potent anti-oxidant properties and displays cardioprotective activity.

METHODS AND RESULTS: Human aortic endothelial cells (HAECs) were pretreated with various concentrations (primarily 50μg/mL) of Aronia Melanocarpa fruit extract prior to treatment with TNFα (10 ng/mL) for various periods of time. The surface protein and mRNA expression of ICAM-1 and VCAM-1 were determined using flow cytometry and real-time RT-PCR, respectively. Adhesion of peripheral blood mononuclear leucocytes(PBMLs) to TNFα-treated HAECs was evaluated by an adhesion assay. Activation of NF-κB was evaluated by measuring NF-κB p65 phosphorylation using flow cytometry. ROS production was determined by reduction in fluorescent 2',7'-dichlorofluorescein diacetate (DCFH-DA). Tested A. Melanocarpa extract significantly inhibited the expression of ICAM-1 and VCAM-1, attenuated the phosphorylation of NF-κB p65 and decreased intracellular ROS production in TNFα-treated HAECs.

CONCLUSION: We conclude that A. Melanocarpa fruit extract exhibits anti-inflammatory effects in HAECs by inhibiting the expression of endothelial CAMs, activation of NF-κB and production of ROS.

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Sayer Ji
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