Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency: a double-blind placebo-controlled randomized clinical trial.
Clin Endocrinol (Oxf). 2018 Sep 24. Epub 2018 Sep 24. PMID: 30246883
BACKGROUND & AIMS: Low serum 25-hydroxy-vitamin D (25OHD) is common in obese people. Obesity is associated with a state of low-grade inflammation (meta-inflammation). There is increasing evidence indicating that vitamin D has anti-adipogenic activity and immunoregulatory effect. This study aimed to assess the effect of vitamin D supplementation on meta-inflammation and fat mass in obese subjects with vitamin D deficiency.
MATERIALS AND METHODS: In this double-blind placebo-controlled randomized clinical trial, 44 obese subjects with vitamin D deficiency (25OHD<50 nmol/L) were assigned into vitamin D (a weight reduction diet + bolus weekly dose of 50000 IU vitamin D) or placebo group (weight reduction diet + edible paraffin weekly) for 12 weeks. Weight, fat mass and serum levels of 25OHD, Calcium, Parathyroid hormone (PTH), Monocyte chemoattractant protein 1 (MCP-1), Interleukin-1β (IL-1β), and Toll like receptor 4 (TLR-4) were assessed before and after the intervention.
RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P<0.001), and significant decrease in PTH (P<0.001), MCP-1 (p<0.05), IL-1β (p<0.05), and TLR-4 (P<0.05); compared to the baseline values in vitamin D group. Weight, BMI and fat mass decreased in both groups (P<0.05). Between the groups, there were significant decrease in weight, fat mass and serum MCP-1 concentrations and significant increase in serum 25OHD and PTH concentrations after intervention with vitamin D supplementation compared to placebo (p<0.05).
CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination weight loss diet resulted in weight, fat mass, and MCP-1 decrease. Weight loss and vitamin D supplementation may act synergistically to reduce levels of meta-inflammation. This article is protected by copyright. All rights reserved.