Wheat gluten contains a novel opioid peptide named gluten exorphin C. - GreenMedInfo Summary
Gluten exorphin C. A novel opioid peptide derived from wheat gluten.
FEBS Lett. 1993 Jan 18;316(1):17-9. PMID: 8422933
Research Control Department, Nisshin Flour Milling Co., Ltd., Nihonbashi, Tokyo, Japan.
A novel opioid peptide, Tyr-Pro-Ile-Ser-Leu, was isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten. Its IC50 values were 40 microM and 13.5 microM in the GPI and MVD assays, respectively. This peptide was named gluten exorphin C. Gluten exorphin C had a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N terminal Tyr was the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu were synthesized to study its structure-activity relationship. Peptides in which X was an aromatic amino acid or an aliphatic hydrophobic amino acid had opioid activity.