Article Publish Status: FREE
Abstract Title:

Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells.

Abstract Source:

Asian Pac J Cancer Prev. 2015 ;16(2):761-7. PMID: 25684522

Abstract Author(s):

Mirna Tawil, Amira Bekdash, Mohammad Mroueh, Costantine F Daher, Ralph J Abi-Habib

Article Affiliation:

Mirna Tawil

Abstract:

In this study, we used Daucus carota oil extract (DCOE) to target acute myeloid leukemia (AML) cells. All the AML cell lines tested were sensitive to the extract while peripheral mononuclear cells were not. Analysis of mechanism of cell death showed an increase in cells positive for annexinV and for active caspases, indicating that DCOE induces apoptotic cell death in AML. Inhibition of the MAPK pathway decreased sensitivity of AML cells to DCOE, indicating that cytotoxicity may be dependent on its activity. In conclusion, DCOE induces selective apoptosis in AML cells, possibly through a MAPK-dependent mechanism.

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.