Abstract Title:

Anti-HCV bioactivity of pseudoguaianolides from Parthenium hispitum.

Abstract Source:

J Nat Prod. 2007 Apr;70(4):604-7. Epub 2007 Feb 10. PMID: 17291045

Abstract Author(s):

Jin-Feng Hu, Rupal Patel, Bin Li, Eliane Garo, Grayson W Hough, Matt G Goering, Hye-Dong Yoo, Mark O'neil-Johnson, Gary R Eldridge


Five new (1-5) and four known (6-9) C14-oxygenated 1alpha-hydroxy-11(13)-pseudoguaien-6beta,12-olides with potent inhibition of hepatitis C virus (HCV) replication were obtained from Parthenium hispitum via high-throughput natural product chemistry methods. A semipreparative HPLC system was used to purify these compounds. The miniaturization of the structure elucidation and dereplication for the mass-limited samples were performed primarily utilizing a capillary-scale NMR probe. Compounds 2-4 were found to possess in vitro anti-HCV activity in the subgenomic HCV replicon system containing luciferase reporter with significant inhibition above 90% at 2 microM concentration.

Study Type : Plant Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1307) : AC(596)

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