Abstract Title:

Effect of Withania somnifer on CD38 expression on CD8+ T lymphocytes among patients of HIV infection.

Abstract Source:

Clin Immunol. 2019 Apr 17. Epub 2019 Apr 17. PMID: 31004791

Abstract Author(s):

Shesh Prakash Maurya, Bimal Kumar Das, Ravinder Singh, Sonu Tyagi

Article Affiliation:

Shesh Prakash Maurya


CD38 on CD8 + T cells is considered a reliable marker of HIV disease progression. Withania somnifer, a traditional ayurvedic medicine, has Th1 immunomodulatory properties. PBMCs from 38 HIV patients were exposed to Withania somnifer root extract at standardized concentration. An overall decline in the percentage of CD38 expressing CD8 + T lymphocytes was observed, though the statistical significance was varied with different categories of HIV patients. Withania somnifer could have promising impact on HIV disease and therefore warrants a further study on larger parameters.

Study Type : Human In Vitro

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