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Article Publish Status: FREE
Abstract Title:

Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-κB and MAPK pathways.

Abstract Source:

BMC Microbiol. 2020 Jul 28 ;20(1):227. Epub 2020 Jul 28. PMID: 32723300

Abstract Author(s):

Ying Chu, Xiaowen Lv, Longfeng Zhang, Xingli Fu, Siwei Song, Airong Su, Deyan Chen, Lianhong Xu, Yongfang Wang, Zhiwei Wu, Zhihua Yun

Article Affiliation:

Ying Chu

Abstract:

BACKGROUND: Wogonin, a natural flavonoid-like chemical compound, exhibits anti-inflammatory, antitumor, antiviral, neuroprotective, and anxiolytic effects by modulating a variety of cellular signaling pathways including PI3K-Akt, p53, nuclear factorκB (NF-κB), mitogen-activated protein kinase (MAPK) pathways. In this study, its antiviral effect against herpes simplex virus (HSV) type 1 and 2 (HSV-1 and HSV-2) replication was investigated.

RESULTS: Wogonin suppressed HSV-2-induced cytopathic effect (CPE) and reduced viral mRNA transcription, viral protein synthesis, and infectious virion particle titers in a dose-dependent manner. A time-of-drug-addition assay demonstrated that wogonin acted as a postentry viral inhibitor. Wogonin also significantly reduced HSV-induced NF-κB and MAPK pathway activation, which has previously been demonstrated to be important for viral replication.

CONCLUSIONS: Our results suggest that the anti-herpes effect of wogonin may be mediated by modulation of cellular NF-κB and JNK/p38 MAPK pathways and imply that wogonin may be useful as an anti-HSV agent.

Study Type : In Vitro Study

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