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Abstract Title:

Xanthohumol prolongs lifespan and decreases stress-induced mortality in Drosophila melanogaster.

Abstract Source:

Comp Biochem Physiol C Toxicol Pharmacol. 2021 Feb 4 ;244:108994. Epub 2021 Feb 4. PMID: 33549830

Abstract Author(s):

Nattapong Wongchum, Ananya Dechakhamphu

Article Affiliation:

Nattapong Wongchum

Abstract:

Aging is a significant risk factor that links to the genesis of human diseases. The capacity to scavenge free radicals and adapt to various stresses is essential for expanding living organisms' lifespan. The evidences on the promotion of longevity by dietary supplementation are growing. Drosophila or fruit fly is one of the most effective models for the evaluation of anti-aging compounds. Xanthohumol (XN) is a potential bioactive substance for the prevention and treatment of many diseases. The previous studies have reported its potent activities as antioxidant, anticancer, anti-inflammatory, antiviral, antibacterial antiplasmodial, and antiobesity. In this study, the effect of XN supplementation on the lifespan extension was investigated in Drosophila melanogaster. The effects of XN on the improvement of the recovery from cold and heat shock, the resistance to starvation stress, and free radical-induced oxidative stress in XN-treated flies were also evaluated. Results showed that supplementation with XN at 0.5 mg/mL diet extended the mean lifespan by 14.89%. This was consistent with a significant improvement of locomotor activity of the Drosophila fed with an XN-mixed diet compared with those fed with a control diet. XN supplementation significantly increased the antioxidant enzyme activities at both 25and 40 days. Drosophila treated with XN exhibited increased survival after exposure to hydrogen peroxide and paraquat. Finally, XN supplementation improved the recovery from cold and heat shock, the resistance to starvation stress, and acetic acid-induced stress. The present study shows that dietary supplementation with XN revealed the longevity effect and ameliorated stress-induced mortality in Drosophila.

Study Type : Insect Study
Additional Links
Pharmacological Actions : Antioxidants : CK(21528) : AC(13231)

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